Perkinston is an unincorporated community in central Stone County, Mississippi, United States. It is situated along U.S. Highway 49, approximately five miles south of Wiggins. The community is part of the Gulfport–Biloxi, Mississippi Metropolitan Statistical Area. Established in 1880, Perkinston is the oldest settlement in Stone County. The village is named for John C. Perkins (1840—1928), who homesteaded the area after serving in the Confederate Army.